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Regimen 5-FU + Leucovorin20

Irinotecan

Irinotecan + 5-FU/LV21

Capecitabine

Capecitabine + irinotecan

Oxaliplatin + 5-FU/LV22

Oxaliplatin + capecitabine

Cetuximab

Cetuximab + irinotecan

20

Mayo treatment method.

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FOLFIRI treatment method.

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FOLFOX treatment method.

Appendix: Composition and Dosages of the Chemotherapy Regimen

1st Drug 425 mg of 5-FU/m2/day for

2nd Drug 20 mg of

days 1-5, every 4 weeks

Leucovorin/m2/day for days 1-5, every 4 weeks

3rd Drug

200 mg of Leucovorin/m2 on day 1 and day 2, every 2 weeks

125 mg of irinotecan per week/m2 for 4 weeks, every 6 weeks 180 mg of irinotecan/m2 on day 1, every 2 weeks

1,000 mg of 5-FU/m2 on day 1 and 2, every 2 weeks

2,500 mg of capecitabine per m2/day for days 1-14, every 3 weeks 70 mg of irinotecan/m2/week, every 6 weeks 85 mg of oxaliplatin per m2 on day 1, every 2 weeks 130 mg of oxaliplatin per m2 on day 1, every 3 weeks 400 mg of cetuximab per m2 on day 1; then 250 mg/m2 once a week, every 6 weeks 400 mg of cetuximab per m2 on day 1; then 250

2,000 mg of capecitabine per m2/day for days 1-14, every 3 weeks 1,000 mg of 5-FU/m2 on day 1 and day 2, every 2 weeks 1,700 mg of capecitabine per m2/day for days 1-14, every 3 weeks

125 mg of irinotecan per week/m2 for 4 weeks,

200 mg of Leucovorin/m2 on day 1 and day 2, every 2 weeks

4th Drug

21

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