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every 6 weeks

85 mg of oxaliplatin per m2 on day 1, every 2 weeks 180 mg of irinotecan/m2 on day 1, every 2 weeks

1,000 mg of 5-FU/m2 on day 1 and day 2, every 2 weeks 1,000 mg of 5-FU/m2 on day 1 and 2, every 2 weeks

130 mg of irinotecan/m2 on day 1, every 3 weeks

1,700 mg of capecitabine per m2/day for days 1-14, every 3 weeks

Bevacizumab + oxaliplatin + 5-FU/LV

mg/m2 once a week, every 6 weeks 5 mg of bevacizumab per kg, every 2 weeks

Bevacizumab + irinotecan + 5-FU/LV

5 mg of bevacizumab per kg, every 2 weeks

Bevacizumab + oxaliplatin + capecitabine23

7.5 mg of bevacizumab per kg, every 3 weeks

200 mg of Leucovorin/m2 on day 1 and day 2, every 2 weeks 200 mg of Leucovorin/m2 on day 1 and day 2, every 2 weeks

Notes: each regimen is assumed to last for 24 weeks. The four-week 5-FU + Leucovorin regimen, for example, is assumed to be repeated six times during a patient’s treatment cycle. mg = milligram of active ingredient; m2 = meter squared of a patient’s surface area; kg = kilogram of a patient’s weight. We price the regimens for a patient who has a surface area of 1.7 m2 and weighs 80 kilograms.

Source: National Comprehensive Cancer Network, Colon Cancer, Version 2.2006; package inserts.

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CAPOX treatment method.

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