Layers of Colon Wall
Graphic from CS Steering Committee Training Materials
An understanding of the make-up of the colon wall is also needed when trying to determine tumor involvement and stage of disease. The wall of the colon includes several layers. The first layer is the mucosa. The mucosa of the colon includes epithelium, lamina propria, and muscular mucosa. The submucosa is a layer of loose connective tissue. The muscularis propria is a layer of muscle tissue. The subserosa is the last layer of tissue before the serosa or peritoneum.