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National Program of Cancer Registries - page 92 / 93

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Chemotherapy for Colon and Rectum

  • Single-agent chemotherapy

    • 5-FU, Vincristine, Irinotecan, Oxaliplatin, Capecitabine, Bevacizumab, and Cetuximab

  • Multiagent chemotherapy

    • FOLFIRI: folic acid (ancillary drug), 5-FU (chemo), Irinotecan (chemo)

    • FOLFOX: Oxaliplatin (chemo), 5-FU (chemo), Leucovorin (ancillary drug)

    • 5-FU and Vincristine

Chemotherapy may given to patients diagnosed at higher stage as adjuvant therapy post-operatively. Chemotherapy drugs given to treat colon and rectal cancer include 5-FU (AKA Fluorouracil, Floxuridine), Vincristine, Irinotecan, Oxaliplatin, Capecitabine, Bevacizumab, and Cetuximab. Most chemotherapy agents are given intravenously, but Capecitabine is taken orally. Multi-agent regimens include FOLFIRI [folic acid (ancillary drug), 5-FU (chemo), Irinotecan (chemo)], FOLFOX [Oxaliplatin (chemo), 5-FU (chemo), Leucovorin (ancillary drug)], 5-FU and Vincristine. Read the health record carefully to determine if chemotherapy was first course or subsequent therapy. Only code first course therapy in this data item. Ancillary drugs such as Leucovorin and folic acid are not coded as treatment. However, some immunotherapy drugs are given with chemotherapy. If Levamisole or Interferon are given with 5-FU, they are coded as immunotherapy.

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