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Cell cycle phase specific

Table 1-1. Cell cycle phase-specific chemotherapeutic agents

Phase of greatest activity ClassType Characteristic agents

Gap 1 (G1)Natural productEnzymeAsparaginase

HormoneCorticosteroid Prednisone

G1/S JunctionAntimetabolitePurine analogCladribine

DNA synthesis (S)AntimetabolitePyrinidine analogCytarabine,

fluorouracil,

              gemcitabine

AntimetaboliteFolic acid analog               Methotrexate,

AntimetabolitePurine analogthioguanine,         

fludarabine

Natural productTopoisomerase 1

inhibitorTopotecan

Miscellaneous Substituted ureaHydroxyurea

Gap 2 (G)Natural productAntibioticBleomycin

Natural productTopoisomerase II

inhibitorEtoposide

Natural productMicrotubule

polymerizationPaclitaxel (Taxol)

and stablization

Mitosis (M) Natural productMitotic inhibitor Vinblastine,          

vincristine

vindesine, vinorelbine

Cell cycle specific and non specific drugs

Table 1-2.  Cell cycle-specific and cell cycle-nonspecific chemotherapeutic agents

ClassTypeCharacteristic agents

Cell cycle specific

Alkylating agent Nitrogen mustardChlorambucil,

   Cyclophosphamide

    Melphalan

Alkyl sulfonateBusulfan

TriazeneDacarbazine

Metal SaltCisplatin, carboplatin

Natural product AntibioticDactinomycin,

 daunorubicin

 doxorubicin

 idarubicin

Cell cycle-nonspecific

Alkylating agentNitrogen mustardMechlorethamine

nitrosoureaCarmustine,

    lomustine

Drug resistance

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