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10 / 21

7

329 ± 94

253 ± 94

14

265 ± 107

181 ± 103

30

231 ± 119

171 ± 117

60

162 ± 107

99 ± 84

Serum fructosamine: mean and range Serum Fructosamine (µmol/L)

Pre-treatment (n=14)

Day 30 (n=13)

660 69

546 150

569 to 787

301 to 848

Mean fructosamine decreased at Days 30 and 60 compared to pre-treatment. As was observed with the VAS score, the serum fructosamine concentration varied between cats. The mean fructosamine concentrations and range for fructosamine

at each time are summarized in Table 5.

Table 5:

Mean SD Range

Day 60 (n=12)

462 157 229 to 707

Dose

Day 7

Day 14

Day30

Day 60

(n=14)

(n=14)

(n=13)

(n=12)

1.7 ± 0.7

2.7 ± 0.9

3.2 ± 0.8

3.6 ± 1.8

1

1

2

1

3

4

5

7

All cats received insulin injections twice daily at approximately 12-hour intervals. Initial doses were 1 to 2 units per injection. The dose was adjusted to effect and was variable. The mean dose and dose range are summarized in Table 6.

Table 6: VETSULIN dose range for study cats

Mean dose (IU per injection) ± SD

Minimum dose (IU per injection)

Maximum dose (IU per injection)

(g) Adverse Reactions: No injection site reactions were reported by cat owners or investigators. No clinical signs attributable to hypoglycemia were observed. Hypoglycemia (defined as blood glucose 50 mg/dL) without clinical signs occurred in six cats on eight occasions and were treated empirically with oral caloric supplements in four cases. Four cats reported to have normal activity at enrollment were reported to be lethargic or to have decreased activity at six times during the study treatment period. Lethargy and decreased activity did not appear to be associated with hypoglycemia. Blood glucose curve values were normal to elevated five of the six times lethargy or decreased activity were reported, and the investigators increased or did not change the insulin dose in all but one case. Lethargy resolved for two cats and improved for one cat by the end of the study. The fourth cat was euthanized shortly after the Day 14 evaluation at the owner’s request. Chronic

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