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0

4/77=5.2%

2.1%

11.5%

7

18/77=23.4%

15.6%

33.5%

14

36/77=46.8%

36.3%

58.2%

30

42/76=55.3%

44.9%

66.6%

60

57/76=75.0%

65.6%

83.7%

180

52/73=71.2%

62.2%

81.4%

Table 10: Proportion of animals whose average blood glucose < 300 mg/dL

Day

Proportion < 300 mg/dL

90% Confidence Interval Limits

Lower

Upper

0

0/77=0%

--

--

7

13/77=16.9%

9.2%

25.5%

14

27/77=35.1%

23.7%

47.1%

30

40/76=52.6%

40.8%

66.0%

60

55/76=72.4%

62.6%

83.4%

180

51/73=69.9%

60.8%

82.3%

The number and percentage of cats with a mean blood glucose nadir < 200 mg/dL on Days 7, 14, 30, 60, and 180 were increased compared to Day 0. These values and their 90% lower confidence bounds are summarized in Table 11.

Lower

Upper

Table 11:

Proportion of animals whose blood glucose nadir < 200 mg/dL

Day

Proportion < 200 mg/dL

90% Confidence Interval Limits

Day

n

Mean

SD

0

77

607.3

102.7

30

75

487.8

133.3

60

75

453.7

145.1

180

72

454.8

145.9

The mean fructosamine concentration on Day 0 was significantly (P <0.0001) reduced on Days 30, 60, and 180 compared to Day 0 as summarized in Table 12.

Table 12: Analysis of fructosamine

Most cats were started on 1 to 2 IU twice daily at approximately 12 hour intervals. Two cats were started on once daily insulin and one cat was started at 3 IU twice daily. The dose was adjusted to effect during the study. The mean dose and dose range are summarized in Table 13.

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