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measures general linear mixed model using the MIXED procedure of SAS Version 9.1.3.

The two-sided 90% confidence intervals on the proportion of cats whose average blood glucose was below 300 mg/dL and whose blood glucose nadir was below 200 mg/dL were constructed based on the binary response of whether or not a cat’s glucose was below the threshold and were analyzed as repeated measures generalized linear mixed models using the GLIMMIX procedure of SAS Version 9.1.3.

(f) Results: Mean VAS scores improved during the study period. VAS score mean, mean change, and range are summarized in Table 2.

Day 0

Day 7

Day 14

Day 30

Day 60

VAS (mm)

(n=14)

(n=14)

(n=14)

(n=13)

(n=12)

Mean score ± SD*

95 ± 10

65 ± 28

43 ± 26

40 ± 32

20 ± 23

Mean change ± SD

-

30 ± 29

52 ± 26

55 ± 32

74 ±25

Range of change

-

0 to 99

4 to 87

6 to 92

5 to 98

Table 2: Mean VAS score, mean change and range of change

*SD = Standard Deviation

Categorical

Day 0

Day 7

Day 14

Day 30

Day 60

Score

(n=14)

(n=14)

(n=14)

(n=13)

(n=12)

Poor

14 (100%)

10 (72%)

6 (43%)

5 (38%)

1 (8%)

Adequate

0

3 (21%)

7 (50%)

4 (31%)

6 (50 %)

Good

0

1 (7%)

1 (7%)

4 (31%)

5 (42%)

Categorical evaluation of diabetes control showed improvement from poor to adequate or good over the study period. All cats were evaluated as poor diabetic control at the start of the study. By Day 60, five cats were judged to have good diabetic control, 6 to have adequate control, and 1 to have poor control.

Categorical evaluation results are summarized in Table 3.

Table 3:

Categorical evaluations summary

Study population glucose curve means and mean nadirs for Days 0, 7, 14, 30, and 60 were calculated to evaluate for reduction of hyperglycemia. The mean blood glucose concentration was progressively reduced from 354 ± 68 mg/dL pre- treatment (Day 0) to 162 ± 107 mg/dL at the end of the study (Day 60). The mean blood glucose nadir was likewise reduced from 321 ± 77 mg/dL pre-treatment (Day 0) to 99 ± 84 mg/dL (Day 60). Blood glucose concentration mean and mean nadir results are summarized in Table 4.

Table 4: Mean blood glucose concentration and nadir comparison for 10- hour blood glucose curves

Day

0

Mean glucose ± SD (mg/dL)

Mean glucose nadir ± SD (mg/dL)

354 ± 68

321 ± 77

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