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California Mechanical Code (Part 4, Title 24, California Code of Regulations) - page 4 / 49





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505.3 Makeup Air. Makeup air shall be provided to replenish air exhausted by the ventilation system. Makeup-air intakes shall be located so as to avoid r e c i r c u l a t i o n o f c o n t a m i n a t e d a i r w i t h i n e n c l o s u r e s . 5 0 5 . 4 H o o d s a n d E n c l o s u r e s . H o o d s a n d enclosures shall be used when contaminants originate in a concentrated area. The design of the hood or enclosure shall be such that air currents created by the exhaust systems will capture the contaminants and transport them directly to the exhaust duct. The volume of air shall be sufficient to dilute explosive or flammable vapors, fumes, or dusts as set forth in Section 505.2. Hoods of steel shall have a base metal thickness not less than 0.027 inch (0.69 mm) (No. 22 gauge) for Class 1 and Class 5 metal duct systems; 0.033 inch (0.84 mm) (No. 20 gauge) for hoods serving a Class 2 duct system; 0.044 inch (1.12 mm) (No. 18 gauge) for hoods serving a Class 3 duct system; and 0.068 inch (1.73 mm) (No. 14 gauge) for hoods serving a Class 4 duct system.

Approved nonmetallic hoods and duct systems may be used for Class 5 corrosive systems when the corrosive mixture is nonflammable. Metal hoods used with Class 5 duct systems shall be protected with suitable corrosion-resistant material. Edges of hoods shall be rounded. The minimum clearance between hoods and combustible construction shall be the clearance required by the duct system.

505.12 Pharmacies – Compounding Area of Parenteral Solutions. The pharmacy shall have a designated area for the preparation of sterile products for dispensing which shall:


Be ventilated in a manner not interfering with laminar air flow.

Note: For additional pharmacy building standard requirements, see Chapter 12, California Building Code.

505.12.1 Pharmacies – laminar flow biological safety cabinet. In all pharmacies preparing parenteral cytotoxic agents, all compounding shall be conducted within a certified Class II Type A or Class II Type B vertical laminar airflow hood with bag in – bag out design. The pharmacy must ensure that contaminated air plenums that are under positive air pressure are leak tight.

Note: For additional pharmacy building standard requirements, see Chapter 12, California Building Code.

505.12.2 Pharmacies Compounding Paren- terial Solutions from One or More Nonsterile Ingredients. Any pharmacy that compounds sterile injectable products from one or more nonsterile ingredients must compound the medication in one of the following environments:

(a) An ISO class 5 laminar airflow hood within an ISO class 7 cleanroom. The cleanroom must have a positive air pressure differential relative to adjacent areas.

505.3 – 506.2

  • (b)

    An ISO class 5 cleanroom.

  • (c)

    A barrier isolator that provides an ISO class 5

environment for compounding.

5 0 6 . 0 P r o d u c t - C o n v e y i n g D u c t s . 5 0 6 . 1 M a t e r i a l s . M a t e r i a l s u s e d i n p r o d u c t - conveying duct systems shall be suitable for the intended use and shall be of metal.


  • (1)

    Asbestos-cement, concrete, clay, or ceramic materials may be used when it is shown that these materials will be equivalent to metal ducts installed in accordance with this chapter.

  • (2)

    Ducts serving a Class 5 system may be constructed of approved nonmetallic material when the corrosive characteristics of the material being conveyed make a metal system unsuitable and when the mixture being conveyed is nonflammable.

Approved nonmetallic material shall be either a listed product having a flame-spread index of twenty-five (25) or less and a smoke- developed rating of fifty (50) or less on both inside and outside surfaces without evidence of continued progressive combustion, or shall have a flame-spread index of twenty- five (25) or less and shall be installed with an automatic fire-sprinkler protection system inside the duct.

(3) Ducts used in central vacuum cleaning systems within a dwelling unit shall be constructed of materials in compliance with the applicable standards referenced in Chapter 17. Penetrations of fire walls or floor-ceiling or roof-ceiling assemblies shall comply with the Building Code.

Copper or ferrous pipes or conduits extending from within the separation between a garage and dwelling unit to the central vacuuming unit may be used.

Aluminum ducts shall not be used in systems conveying flammable vapors, fumes, or explosive dusts, nor in Class 2, 3, or 4 systems. Galvanized steel and aluminum ducts shall not be used when the temperature of the material being conveyed exceeds 400˚F (205˚C).

Metal ducts used in Class 5 systems that are not resistant to the corrosiveness of the product shall be p r o t e c t e d w i t h a p p r o p r i a t e c o r r o s i o n - r e s i s t a n t m a t e r i a l . 5 0 6 . 2 C o n s t r u c t i o n . D u c t s u s e d f o r c o n v e y i n g products shall be of substantial airtight construction


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