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scavengers of reactive oxygen species (e.g. N-acetylcysteine - NAC), inhibitors of enzymes responsible for their production, NO synthase substrate (L-arginine) and NO donors on the development of blood pressure in the model of spontaneous and L-NAME induced hypertension (the hypertension developed by NO synthase inhibition with nitro-L-arginine methyl ester, LNAME). We demonstrated that scavengers increased activity of NO synthase in tissues and prevented the blood pressure increase as well as structural alterations in the cardiovascular system in L-NAME-induced hypertension (Fig.). In contrary, inhibitors of oxidative enzymes and NO donors did not affect the activity of NO synthase and failed to influence both blood pressure increase and structural alterations in spontaneous hypertension. Taken together, the substances with antioxidant properties along with activating effect on NO synthase have more effective influence on blood pressure decrease than antioxidants without effect on NO synthase activity or NO donors without effect on the level of reactive oxygen species. Moreover, the antioxidants with activating effect on NO synthase are able to prevent vessel thickness and myocardial fibrosis enlargement due to the hypertensive process.

(VEGA: 2/3185/25, 2/3145/25 and APVT: 51-017902, Pecháňová, Kristek, Gerová, Bernátová, Török ,Čačányiová, Kojšová, Jendeková, Cebová, Koprdová, Paulis, Janega).

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GEROVÁ, M. - KRISTEK, F. - ČAČÁNYIOVÁ, S. - CEBOVÁ, M. Acetylcholine and bradykinin enhance hypotension and affect the function of remodelled conduit arteries in SHR and SHR treated with nitric oxide donors. Braz J Med Biol Res Vol. 38, 2005, 959-966

RAUCHOVÁ, H. - PECHÁŇOVÁ, O. - KUNEŠ, J. - VOKURKOVÁ, M. - DOBEŠOVÁ, Z. - ZICHA J. Chronic N-acetylcysteine administration prevents development of hypertension in L-NAME-treated rats: the role of reactive oxygen species.Hypertens Res Vol.28,no.5(2005),475-82

Šimko, F. - Luptak, I. - MatuskovÁ, J. - KrajciroviČovÁ, K. - SumbalovÁ, Z. - KucharskÁ, J. - GvozdjakovÁ, A. - Šimko, J. - BabÁl, P. - PechÁŇovÁ, O. - BernatovÁ, I. L-arginine fails to protect against myocardial remodelling in L-NAME-induced hypertension. Eur J Clin Invest Vol. 5, no.6 (2005), 362-368

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