X hits on this document

Word document

Strong Opioids +/- adjuvant therapy - page 31 / 38

108 views

0 shares

0 downloads

0 comments

31 / 38

Cautions:

Pregnancy, hepatic impairment, cardiovascular disease, reconstituted solution is highly alkaline—extravasation causes tissue necrosis and severe pain; avoid intra-arterial injection; overdosage with cardiorespiratory depression may occur. Some sedative effects may persist for 24 hours. Repeated doses have a cumulative effect.

Interactions:

Drug

Effect of Interaction

Sulphonamides

Effects of thiopental enhanced by sulphonamides1  

ACE Inhibitors

enhanced hypotensive effect when general anaesthetics given with ACE inhibitors   

Adrenergic Neurone Blockers

enhanced hypotensive effect when general anaesthetics given with adrenergic neurone blockers

Alpha-blockers

enhanced hypotensive effect when general anaesthetics given with alpha-blockers

Angiotensin-II Receptor Antagonists

enhanced hypotensive effect when general anaesthetics given with angiotensin-II receptor antagonists

Antidepressants, Tricyclic

increased risk of arrhythmias and hypotension when general anaesthetics given with tricyclics   

Antipsychotics

enhanced hypotensive effect when general anaesthetics given with antipsychotics  Increased risk of toxicity with myelosuppressive drugs

Anxiolytics and Hypnotics

increased sedative effect when general anaesthetics given with anxiolytics and hypnotics   

Beta-blockers

enhanced hypotensive effect when general anaesthetics given with beta-blockers  Since systemic absorption may follow topical application of beta-blockers to the eye the possibility of interactions, in particular, with drugs such as verapamil should be borne in mind

Calcium-channel Blockers

enhanced hypotensive effect when general anaesthetics given with calcium-channel blockers  Dihydropyridine calcium-channel blockers include amlodipine, felodipine, isradipine, lacidipine, lercanidipine, nicardipine, nifedipine, nimodipine, and nisoldipine

Clonidine

enhanced hypotensive effect when general anaesthetics given with clonidine   

Diazoxide

enhanced hypotensive effect when general anaesthetics given with diazoxide

Diuretics

enhanced hypotensive effect when general anaesthetics given with diuretics   

Hydralazine

enhanced hypotensive effect when general anaesthetics given with hydralazine

Isoniazid

general anaesthetics possibly potentiate hepatotoxicity of isoniazid   

MAOIs

Because of hazardous interactions between general anaesthetics and MAOIs , MAOIs should normally be stopped 2 weeks before surgery  

Methyldopa   

enhanced hypotensive effect when general anaesthetics given with methyldopa

Minoxidil

enhanced hypotensive effect when general anaesthetics given with minoxidil   

Moxonidine  

enhanced hypotensive effect when general anaesthetics given with moxonidine

1 The text in bold is the specific interaction for thiopental, the rest are interactions relevant to all general anaesthetics.

31

Document info
Document views108
Page views108
Page last viewedSun Dec 11 13:07:31 UTC 2016
Pages38
Paragraphs1579
Words11304

Comments