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Nitrates

enhanced hypotensive effect when general anaesthetics given with nitrates   

Nitroprusside

enhanced hypotensive effect when general anaesthetics given with nitroprusside   

Vancomycin

hypersensitivity-like reactions can occur when general anaesthetics given with intravenous vancomycin

Verapamil

general anaesthetics enhance hypotensive effect of verapamil (also AV delay)  

Monitoring:

Careful monitoring of pulse oximetry, capnometry and vital signs, with careful airway and ventilatory control.

Dose:

Induction of general anaesthesia, by intravenous injection usually as a 2.5% (25 mg/mL) solution, in fit premedicated adults, initially 100–150 mg (reduced in elderly or debilitated) over 10–15 seconds (longer in elderly or debilitated), followed by further quantity if necessary according to response after 30–60 seconds; or up to 4 mg/kg (max. 500mg); child induction 2–7 mg/kg

Raised intracranial pressure, by intravenous injection, 1.5–3 mg/kg, repeated as required

Status epilepticus (only if other measures fail), by intravenous injection as a 2.5% (25 mg/mL) solution, 75–125 mg as a single dose

References

( Memory Loss and the Brain. The Newsletter of the memory disorders project at Rutgers University. Glossary: Neurotransmitter.[homepage on the internet]. C2005 [updated 2005, Autumn, cited July 16]. Available from http://www.memorylossonline.com/glossary/neurotransmitter.html

( Biology Mad. Designed for students studying AQA (spec. A) Biology. Picture of a nerve synapse. A2 Biology, Module 6, Nervous System. [homepage on the internet]. C2006 [cited July 16]. Available from http://www.biologymad.com/master.html?http://www.biologymad.com/NervousSystem/NervousSystem.htm

Sources:

BNF 51

Berne RM, Levy MN, Koeppen BM, Stanton BA, Physiology, 5th ed. Mosby ·2004

Page C, Curtis M, Sutter M, Walker M, Hoffman B. Integrated Pharmamology 2nd and 3rd ed. Mosby 2005, 2006

Sevoflurane by Charlotte Stone

Mode of operation

Sevoflurane is an inhalational anaesthetic. Inhalational anaesthetics may be gases or volatile liquids. They can be used both for induction and maintenance of anaesthesia and may also be used following induction with an intravenous anaesthetic.

Sevoflurane is a rapid acting volatile liquid anaesthetic. Patients anaesthetised with sevoflurane may require early postoperative pain relief as emergence and recovery are particularly rapid.

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