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Tricyclics.

Increased risk of arrhythmias and hypotension when general anaesthetics given with tricyclics.

Antipsychotics.

Enhanced hypotensive effect when general anaesthetics given with antipsychotics.

Anxiolytics and hypnotics.

Increased sedative effect when general anaesthetics given with anxiolytics and hypnotics

Beta-blockers.

Enhanced hypotensive effect when general anaesthetics given with beta-blockers.

Calcium-channel blockers.

Enhanced hypotensive effect when general anaesthetics given with calcium-channel blockers.

Clonidine.

Enhanced hypotensive effect when general anaesthetics given with clonidine.

Diazoxide.

Enhanced hypotensive effect when general anaesthetics given with diazoxide

Diuretics.

Enhanced hypotensive effect when general anaesthetics given with diuretics.

Hydralazine.

Enhanced hypotensive effect when general anaesthetics given with hydralazine.

Isoniazid.

General anaesthetics possibly potentiate hepatotoxicity of isoniazid.

MAOI’s

Because of hazardous interactions between general anaesthetics and MAOIs, MAOIs should normally be stopped 2 weeks before surgery.

Methyldopa.

Enhanced hypotensive effect when general anaesthetics given with methyldopa.

Minoxidil.

Enhanced hypotensive effect when general anaesthetics given with minoxidil.

Moxonidine.

Enhanced hypotensive effect when general anaesthetics given with moxonidine.

Nitrates.

Enhanced hypotensive effect when general anaesthetics given with nitrates.

Nitroprusside.

Enhanced hypotensive effect when general anaesthetics given with nitroprusside.

Vancomycin.

Hypersensitivity-like reactions can occur when general anaesthetics given with intravenous vancomycin.

Verapamil.

General anaesthetics enhance hypotensive effect of verapamil (also AV delay).

Monitoring.

Dose and effects monitored by anaesthetist during procedure.

Dose

Dose measursed using sing a specifically calibrated vaporiser.

Induction Dose - up to 5% in oxygen or nitrous oxide–oxygen; child up to 7%.

Maintenance Dose -  0.5–3%.

Nitrous Oxide (N2O) by Andrew Scott Pearson

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