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hyperthermia

increased gastric pressure

rash

flushing

Contra-indications:  family history of malignant hyperthermia, low plasma cholinesterase activity (including severe liver disease), hyperkalaemia; major trauma, severe burns, neurological disease involving acute wasting of major muscle, prolonged immobilisation—risk of hyperkalaemia, personal or family history of congenital myotonic disease, Duchenne muscular dystrophy

Cautions:  Pregnancy, with cardiac, respiratory or neuromuscular disease; raised intra-ocular pressure (avoid in penetrating eye injury); severe sepsis (risk of hyperkalaemia).

Interactions:  None

Monitoring:    None

Dose

By intravenous injection, initially 1 mg/kg; maintenance, usually 0.5–1 mg/kg at 5–10 minute intervals; max. 500 mg/hour; neonate and infant under 1 year, 2 mg/kg; child over 1 year, 1 mg/kg

By intravenous infusion of a solution containing 1–2 mg/mL (0.1–0.2%), 2.5–4 mg/minute; max. 500 mg/hour; child reduce infusion rate according to body-weight

By intramuscular injection, infant under 1 year, up to 4–5 mg/kg; child over 1 year, up to 4 mg/kg; max. 150 mg

i Memory Loss and the Brain. The Newsletter of the memory disorders project at Rutgers University. Glossary: Neurotransmitter.[homepage on the internet]. C2005 [updated 2005, Autumn, cited July 16]. Available from http://www.memorylossonline.com/glossary/neurotransmitter.html

ii Biology Mad. Designed for students studying AQA (spec. A) Biology. Picture of a nerve synapse. A2 Biology, Module 6, Nervous System. [homepage on the internet]. C2006 [cited July 16]. Available from http://www.biologymad.com/master.html?http://www.biologymad.com/NervousSystem/NervousSystem.htm

Sources:

BNF 51

Berne RM, Levy MN, Koeppen BM, Stanton BA, Physiology, 5th ed. Mosby ·2004

Page C, Curtis M, Sutter M, Walker M, Hoffman B. Integrated Pharmamology 2nd and 3rd ed. Mosby 2005, 2006

Propofol by Rachel Seville

Mode of operation:

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