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antimuscarinic drug may be necessary to prevent this. Monitor blood-lipid concentration if risk of fat overload or if sedation longer than 3 days.

Dose: 1% injection

Induction of anaesthesia, by intravenous injection or infusion, 1.5–2.5 mg/kg (less in those over 55 years) at a rate of 20–40 mg every 10 seconds; child over 1 month, administer slowly until response (usual dose in child over 8 years 2.5 mg/kg, may need more in younger child e.g. 2.5–4 mg/kg).

Maintenance of anaesthesia, by intravenous injection, 25–50 mg repeated according to response or by intravenous infusion, 4–12 mg/kg/hour; child over 3 years, by intravenous infusion, 9–15 mg/kg/hour.

Propofol-Lipuro® may be used for maintenance of anaesthesia in child over 1 month, by intravenous infusion, 9–15 mg/kg/hour.

Sedation in intensive care, by intravenous infusion, adult over 17 years, 0.3–4 mg/kg/hour.

Sedation for surgical and diagnostic procedures, initially by intravenous injection over 1–5 minutes, 0.5–1 mg/kg; maintenance, by intravenous infusion, 1.5–4.5 mg/kg/hour (additionally, if rapid increase in sedation required, by intravenous injection, 10–20 mg); those over 55 years may require lower dose; child and adolescent under 17 years not recommended.

Dose: 2% injection

Induction of anaesthesia, by intravenous infusion, 1.5–2.5 mg/kg (less in those over 55 years) at a rate of 20–40 mg every 10 seconds; child over 3 years, administer slowly until response (usual dose in child over 8 years 2.5 mg/kg, may need more in younger child e.g. 2.5–4 mg/kg).

Maintenance of anaesthesia, by intravenous infusion, 4–12 mg/kg/hour; child over 3 years, by intravenous infusion, 9–15 mg/kg/hour.

Sedation in intensive care, by intravenous infusion, adult over 17 years, 0.3–4 mg/kg/hour.

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