Diclofenac by Laura Potter
Member of arylalkanoic acid group of NSAIDs (but consider it to have properties similar to propionic acid derivates like ibuprofen and naproxen). Advantage over these is less side effects and consequently tried first. Diclofenac is available by prescription only.
Voltarol trade name for Diclofenac (Novartis)
Arthrotec Diclofenac + misoprostol. Used in prophylaxis against NSAID-induced GI ulcers when long-term diclofenac use is indicated. Misoprostol is a PGE1-derivative.
Diclofenac is indicated in:
Pain and inflammation in rheumatic disease (including juvenile arthritis)
Other musculoskeletal disorders
(Diclofenac intermediate risk of severe upper GI side effects)
Bleeding and ulceration
Renal failure provoked if renal impairment pre-existing
PR route rectal irritation
IV route injection site reactions
Reducing side effects:
Take oral formulations with milk/food
Use enteric-coated formulations