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MALIGNANT RISK

Cancer Causes Control. 2010 Jan 19. [Epub ahead of print]

A multi-center prospective cohort study of benign breast disease and risk of subsequent breast cancer.

Kabat GC et al

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, 10461, USA, geoffrey.kabat@einstein.yu.edu.

compared to women with normal pathology / non- proliferative disease, women with proliferative disease without atypia have a modestly increased risk of breast cancer, whereas women with proliferative disease with atypical hyperplasia have a substantially increased risk.

Relative to non-proliferative BBD/normal pathology, the multivariable-

adjusted odds ratio for proliferative lesions without atypia was 1.45 (95% CI 1.10-1.90), and that for atypical hyperplasia was 5.27 (95% CI 2.29- 12.15). n = 1239

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