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Route Inhalation

Species Rat

Value Some positive data exist, but the data are not sufficient for classification Data not available or insufficient for classification Some positive data exist, but the data are not sufficient for classification

Inhalation

Multiple animal species

Ingestion

Multiple animal species Rat Human and animal

Data not available or insufficient for classification Not carcinogenic

Inhalation Inhalation

Carcinogenic Carcinogenic

Titanium Dioxide Quartz Silica

Talc Talc Limestone Oxide Glass Chemicals

In Vitro In vivo

In Vitro

Tris(2,4,6-Dimethylaminomonomethyl)Phenol Titanium Dioxide Titanium Dioxide Quartz Silica

In Vitro In Vitro In vivo In Vitro

Quartz Silica

In vivo

Tris(2,4,6-Dimethylaminomonomethyl)Phenol Titanium Dioxide

Limestone Oxide Glass Chemicals

3M™ EZ Sand Flexible Parts Repair PN 05887, 05891, 05892, 05895, 05896 - Accelerator

02/05/14

Carcinogenicity Name Talc

Not mutagenic Not mutagenic Data not available or insufficient for classification Some positive data exist, but the data are not sufficient for classification Not mutagenic Not mutagenic Not mutagenic Some positive data exist, but the data are not sufficient for classification Some positive data exist, but the data are not sufficient for classification

Route

Value

Species

Test Result

Ingestion

Not toxic to development

Rat

NOAEL 1,600 mg/kg

Ingestion

Not toxic to development

Rat

NOAEL 625 mg/kg/day

Data not available or insufficient for classification Data not available or insufficient for classification Data not available or insufficient for classification Data not available or insufficient for classification

Reproductive Toxicity

Reproductive and/or Developmental Effects

Name

Talc

Limestone

Oxide Glass Chemicals

Tris(2,4,6- Dimethylaminomonomethyl)Phenol Titanium Dioxide

Quartz Silica

Exposure Duration during organogenesi s premating & during gestation

Target Organ(s)

Route

Target Organ(s)

Value

Inhalation

respiratory system

All data are negative

Specific Target Organ Toxicity - single exposure

Name

Limestone

Species

Rat

Tris(2,4,6-

Dimethylaminomonomethy l)Phenol

Inhalation

respiratory irritation

Some positive data exist, but the data are not sufficient for classification

Test Result

NOAEL 0.812 mg/l NOAEL Not available

Exposure Duration 90 minutes

Route

Target Organ(s)

Value

Inhalation

pneumoconiosis

Causes damage to organs

Specific Target Organ Toxicity - repeated exposure

Name

Talc

Species

Test Result

Exposure

Duration

Human

NOAEL Not

occupational

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