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Biosafety Level 4 (BSL-4)

Primary hazards:

respiratory exposure to infectious aerosols

mucous membrane exposure to infectious droplets

accidental sticks with needles or other sharp objects contaminated with infectious material

For example

In late 1960s, 25 laboratory-acquired Marburg infections, including 5 deaths

Workers studying infected monkeys from Uganda

First documented naturally-occurring human case occurred in 1975

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