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P4: Anticancer activity of the landomycin E in vivo, B. Matselyukh

Title:

Prof.Dr.

First Name:

Bohdan

Family Name:

Matselyukh

Position:

Head of Department

Name of organisation:

Institute of Microbiology and Virology of National Academy of Sciences of Ukraine, Department Genetics of Microorganisms

Address:

Zabolotny Str. 154

Postcode:

03143

City:

Kyiv

Country:

Ukraine

Telephone:

+380 44 2663296

Fax:

+380 44 2662379

E-mail:

bohdan@serv.imv.kiev.ua

Website:

Proposed Title

Anticancer activity of the landomycin E in vivo

Abstract

Landomycin E is the new angucycline antibiotic produced by Streptomyces globisporus 1912. It has broad anticancer activity especially against leukemia cells. Investigation of landomycin E in the National Cancer Institute (Bethesda, USA) according to the International Therapeutic Program showed its inhibitory effect against 60 human cancer lines. Clear apoptosis picture of cancer cells caused by landomycin E was observed under luminescence microscope. The proposed Project presents the second stage of landomycin E investigation - study of its anticancer effect in vivo on the cancer models of laboratory animals. The scientific part of Program can be fulfilled in two Ukrainian Institutes - Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine and Institute of Experimental Pathology, Oncology and Radiobiology of NASU.

A. Enterprises Corner

Enterprises looking for complementary partners in research arena and

x

Researchers offer their findings for technology transfer to enterprises

B. Research Corner

Research institutions looking for partners for joint research venture

Potentially interested for continuation of projects preparations on Tuesday afternoon 1 st July

Keywords:

landomycin E

Received: 16/06/2003

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