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P22: Molecular basis of innate immunity and sepsis, R. Jerala

Title:

Dr.

First Name:

Roman

Family Name:

Jerala

Position:

Head

Name of organisation:

National Institute of Chemistry, Laboratory of Biotechnology

Address:

Hajdrihova 19

Postcode:

1000

City:

Ljubljana

Country:

Slovenia

Telephone:

+386 1 476 0335

Fax:

+386 1 476 0300

E-mail:

roiman.Jerala@ki.si  

Website:

Proposed Title

Molecular basis of innate immunity and sepsis

Abstract

Despite of widely effective intensive care accessible bacterial infection induced septic shock is estimated to cause more than 100,000 deaths per year in Europe. Current medical treatment is limited to relieving the symptoms of sepsis rather than blocking its progression. Septic shock is caused by inherently non toxic pathogen associated molecular patterns (PAMPs) triggering a toxic overreaction of the host immune system. Understanding the molecular mechanisms of PAMP recognition might be one key for development of new strategies for therapeutic interference with sepsis pathogenesis. Availability of nucleic acid sequence data provided the basis for identification of human homologs of Drosophila proteins involved in mediation of host responses towards microbial challenge. Physicochemical properties of bacterial products, such as cell wall components, as well as internally localized proteins and nucleic acids, provide molecular patterns (rather than singular molecule structures) representative for whole groups of bacterial species as exemplified by endotoxin representing Gram-negative bacteria. CD14, LBP, Toll-like receptors (TLRs), and MD2 among others have been implicated as pattern recognition receptors (PRRs). The research of our consortium applying hereby will focus on identification and mapping of PRR - agonist interactions leading to outside - in-signal transduction in host immune cells such as macrophages, dendritic, and endothelial cells. Further insight into the structural basis of pathogen- host interactions on a molecular level will provide supportive guidelines for the design of novel immuno-modulating drugs such as inhibitors for cell activation in infections, as well as immuno stimulants in anti oncogenic immunotherapy and adjuvants for vaccination).

A. Enterprises Corner

Enterprises looking for complementary partners in research arena and

Researchers offer their findings for technology transfer to enterprises

B. Research Corner

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Research institutions looking for partners for joint research venture

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Potentially interested for continuation of projects preparations on Tuesday afternoon 1 st July

Keywords:

sepsis, pattern recognition receptors, antimicrobial drugs, drug design

Received: 16/6/2003

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