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International Journal of Applied Pharmaceutics

Vol 2, Issue 3, 2010

Research Article


M O H A N A C H A N D R A N P . S . 1 * , K R I S H N A M O H A N . P . R . 2 , F E L S S A J U 1 , B I N I . K . B 1 , B E E N U B A B U 1 , S H A L I N A K . K . 1

1Department of Pharmaceutics, Nirmala College of Pharmacy, Muvattupuzha, Kerala, 2Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala.

Received: 20 March 2010, Revised and Accepted: 29 April 2010


An attempt has been made for the development of rapidly disintegrating oral tablets of Amlodipine Besylate by direct compressi ferent superdisintegrants were prepared by direct compression m

evaluated for its physicochemical properties and in vitro disso

n behaviour of tablets

formulations containing Crosscarmellose sodium was least and ta

t there was no short dispersion

uper disintegrants were found to be better in the formulation of fast dissolving



Solid dosage forms are the most popular and preferred drug delivery system due to various advantages such as high patient complianc

incorporating the drug in a fast dissolving dosage form5 dissolving tablets of amlodipine besylate by sublimation method has been reported recently6 direct compression process have positioned this technique as an

pediatric and geriatric patients) find difficulty in swallowing tablets

as 50% of the population is affected by and ineffective therapy1 system emerged from the desire to provide the patients with more

he present investigation deals with the development of an effective and

reporting the formulation of amlodipine besylate by direct

technology offers some unique advantages over conventional drug delivery systems in that it offers quick disintegration and dissolution of tablets2

g tablets when placed in mouth disintegrate instantaneously releasing the drug which dissolves or disperse in the saliva and can be

MATERIALS AND METHODS Materials Amlodipine Besylate was obtained as gift sample from Copella


Moreover the dosage combines the advantage of both liquid and

pharynx and esophagus as the saliva passes down into the stomac rom

Methods Preparation of tablets

Fast dispersible tablets containing 10 mg of amlodipine besylate were prepared by direct compression method and the various

and crospovidone were screen Another approach used in developing FDT is by maximizing the pore

dients without magnesium stearate and talc were mixed uniformly

nd Croscarmellose Sodium were used in different ratios and finally the

techniques have been tried by researchers to maximize the pore yields re

prepared powder blend was evaluated for various parameters like index

disintegration of tablet into smaller particles that can dissolve more rapidly than in absence of disintegrants3 of dose even during traveling or other situations where there is no

ed in

were compressed with single station tablet punching machine

Post compression parameters Tablet hardness7

hypertension4 drug and the rate of absorption is often controlled by the rate of

The resistance of tablets to shipping or breakage under the conditions handling before usage depends on its s

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