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Mohanachandran et al.

Int J Appl Pharma, Vol 2, Issue 3, 2010, 1­6

Friability of the tablets was determined using Roshe Friabilato This device subjects the tablets to the combined effect of abrasion and shock in a plastic chamber revolving at 25 rpm and dropping

Dissolution studies12, 13, 14 The study has been carried out in type II apparatus at 75 rpm in 900

ghed sample of tablets was placed in the friabilator and were subjected

besylate dissolved by employing UV absorption at about 259 nm on filtered portions of the solution under test in comparison with a Standard solution having a known concentration of amlodipine besylate RS prepared by dissolving an accurately weighed portion in a small volume of methanol and diluting quantitatively with

Weight variation8 Twenty tablets from each formulation were selected randomly and

Individual tablets were then weighed and was compared with

Friability

In vitro disintegration time The disintegration time for all formulations was carried out using

individually in each tube of disintegration test apparatus and discs

temperature of 37°±2°C and time taken for the entire tablet to

r

spectra for drug and powdered tablets were recorded in a Fourier transform infrared spectrophot o

he

pre warmed at 37⁰ C was replaced into the dissolution medium after each Sampling to maintain the constant volume throughout the te

Wetting time and water absorption ratio10, 11 A piece of paper folded twice was kept in a Petri dish (internal

having a small amount of Rosaline dye powder on the upper

develop a red colour on the upper surface of the tablet was

Rosaline dye powder was followed for determining the water absorption ratio R and it was determined using the following

Drug content15

Twenty tablets were powdered and the blend equivalent to 10 mg of Amlodipine besylate was weighed and dissolved in suitable quantity s

Characterization of Amlodipine besylate tablets FTIR studies

(mg per tablet)

Amlodipine besylate

10

Microcrystalline cellulose

80

10

10

10

10

10

10

10

10

10

10

10

80

80

80

80

80

80

80

80

80

80

80

Ingredients

F1

Table 1: Formulation of fast dissolving tablets of amlodipine besylate

F2

F3

F4

F5

F6

F7

F8

F9

F10

F11

F12

6

Total weight

150

150

150

150

150

150

150

150

150

150

150

150

RESULTS AND DISCUSSION

First nine formulations of amlodipine besylate were prepared with different concentration of three superdisintegrants namely Sodium

prepared and evaluated for various parameters like angle of rep

and

Microcrystalline cellulose was used as the direct compressible ts to

he d and

which found to be having a deleterious effect on the dissolutio used at very low concentration a

ability of blend was also made evident with the angle of repose (range of 21 were

s

containing cros PVP as superdisintegrant at a concentration of

taste of the drug is masked by using sodium saccharin as sweetening

ght er e the f

2

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