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International Journal of Applied Pharmaceutics - page 4 / 6

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Mohanachandran et al.

Int J Appl Pharma, Vol 2, Issue 3, 2010, 1­6

Formulations

Average weight

Hardness

Friability

Kg/cm2

(%)

Table 2: Evaluation of fast dissolving tablets

Wetting time(sec)

Water absorption ratio

Table 3: Evaluation of fast dissolving tablets

Formulations

Disintegration time(sec)

Drug content

(%)

Percentage drug dissolved after 30 minutes

100

90

Cumulative percentage drug dissolved

80

70

60

50

40

30

20

F10 F11 F12

10

0

0

5

10 15 Time in minutes

30

Fig. 4: Comparative dissolution profile of amlodipine besylate tablets containing combination of superdisintegrants f10, f11, f12

the tablet was found to be satisfactory so that the tablet will resist

Croscarmellose sodium having low disintegration time as compared

ity of the tablets was found below 1 % indicating good mechanical

en for the tablet to disintegrate when kept motionless on the tissue paper

formulations

containing

cross

carmellose

sodium

as tructure d in ng he super

disintegrant and it was found to be very less for the formulation containing combination of cros carmellose and sodium starch

disintegration time of all formulated tablets was found to be less from y um increase in the dissolution rate was observed with cros carmellose

enhancement of the dissolution rate with various superdisintegrants was found to be Croscarmellose> Sodium starch glycolate >

4

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