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Singapore Med J 2002 Vol 43(12) : 617-621

Original

Article

Effect of Cassia Auriculata Flowers on Blood Sugar Levels, Serum andTissue Lipids in Streptozotocin Diabetic Rats

L Pari, M Latha

ABSTRACT

Aim of the study: The main aim was to demonstrate the effects of Cassia auriculata flowers on blood glucose and lipid levels in experimental diabetic rats.

Many traditional plant treatments for diabetes mellitus are used throughout the world(5). Few of the traditional plant treatments for diabetes have received scientific scrutiny, and the World Health Organisation has recommended that this area warrants attention(6).

Methodology: Aqueous extract of Cassia auriculata flowers was administered orally and different doses of the extract on blood glucose, haemoglobin, glycosylated haemoglobin, serum and tissue lipids, hexokinase and glucose- 6-phosphatase in streptozotocin-induced diabetic rats were studied. Glibenclamide was used as standard reference drug.

Results: Cassia auriculata flower extract (CFEt), at doses of 0.15, 0.30 and 0.45 g/kg body weight for 30 days, suppressed the elevated blood glucose and lipid levels in diabetic rats. Cassia auriculata at 0.45 g/kg was found to be comparable to glibenclamide.

This paper describes the study of Cassia auriculata L. (Cesalpinaceae, common name: Tanner’s Cassia) a common plant in Asia, has been widely used in

traditional medicine as a cure for rheumatism, conjunctivitis and diabetes(7). In addition, Cassia auriculata has been widely used in Ayurvedic medicine as ‘Avarai Panchaga Choornam’ and the main constituent of Kalpa herbal tea, has come under extensive study in the light of its antidiabetic effects. We have recently reported the antiperoxidative effect of Cassia auriculata flowers in streptozotocin diabetic rats(8). This study was thus initiated with the aim of evaluating the effects of an aqueous extract of Cassia auriculata flowers on the blood glucose level, serum and tissue lipids in streptozotocin diabetic rats.

Conclusion: Our findings indicate that the Cassia auriculata flowers possess antihyperlipidaemic effect in addition to antidiabetic activity.

Keywords: Blood glucose, Cassia auriculata, Carbohydrate enzymes, Insulin, Lipids

Singapore Med J 2002 Vol 43(12):617-621

INTRODUCTION Diabetes mellitus is characterised by hyperglycaemia together with biochemical alterations of glucose and lipid metabolism(1). Liver is an insulin dependent tissue, which plays a pivotal role in glucose and lipid

MATERIALS AND METHODS Animals All the experiments were carried out with male Wistar rats aged seven to eight weeks (180-200 g), obtained from the Central Animal House, Rajah Muthiah Medical College, Annamalai University, India. The animals were housed in polypropylene cages and provided with water and standard pellet diet (Karnataka Agro Food Corporation Limited, Bangalore, India) ad libitum. The animals used in the present study were approved by the ethical committee, Annamalai University.

Department of

Biochemistry Faculty of Science Annamalai University Annamalai Nagar Tamil Nadu-608 002 India

homeostasis and is severely affected during diabetes(2). Liver participates in the uptake, oxidation and metabolic conversion of free fatty acids, synthesis of cholesterol, phospholipids and triglycerides. During diabetes a profound alteration in the concentration and composition of lipid occurs(3). Decreased glycolysis, impeded glycogenesis and increased gluconeogenesis are some of the changes of glucose metabolism in the diabetic liver(4).

Chemicals Streptozotocin was obtained from Himedia Laboratory Limited, Mumbai, India. All other reagents used were of analytical grade.

L Pari, MSc, MPhil, PhD Reader

M Latha, MSc, MPhil, PhD Scholar

Plant Material Cassia auriculata flowers were collected freshly from Neyveli, Cuddalore District, Tamil Nadu, India. The

Correspondence to: Dr L Pari Tel: +914144 38343 Fax: +914144 22265 Email: Paribala@ sancharnet.in

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