X hits on this document

29 views

0 shares

0 downloads

0 comments

11 / 13

Lifetime Dimensions of Psychosis Scale

Schizophrenia Bulletin, Vol. 28, No. 4, 2002

Variable

n

MS Raters

MS Subjects

MS Error

ICC

CO CO CO CD CO (O

Concurrent grandiose/

Dur

62

0.07

0.91

0.21

0.63

manic mood +

Sev

62

0.02

0.79

0.26

0.51

delusions or hallucinationsTot

62

0.02

3.20

0.74

0.62

Deterioration

60

0.00

5.14

0.37

0.87

Complicating factors

63

0.02

0.72

0.18

0.59

0.79

3.41

1.19

0.48

1.95

3.12

0.89

0.56

5.23

12.92

3.99

0.53

Concurrent depressed mood + delusions or hallucinations

Dur Sev Tot

MS = mean squares; sev = severity rating; tot = duration rating +

Note.—dur = duration rating; ICC = intraclass correl severity rating.

ation coefficient;

be tested in different contexts. Finally, its advantages and disadvantages compared with other scales remain to be determined empirically.

We conclude that LDPS version 2 is a rating scale with good interrater reliability that can be used to rate the longitudinal duration and severity of a broad range of psy- chotic and mood disorder pathologies. Copies of the scale and instruction manual are available via the Internet at http://depressiongenetics.med.upenn.edu. Investigators are encouraged to utilize, test, and further improve the scale.

References

Andreasen, N.C. The Scale for the Assessment of Negative Symptoms (SANS): Conceptual and theoretical

foundations. British 7(Suppl):49-58, 1989.

Journal

of

Psychiatry,

Cardno, A.G.; Jones, L.A.; Murphy, K.C.; Asherson, P.; Scott, L.C.; Williams, J.; Owen, M.J.; and McGuffin, P. Factor analysis of schizophrenic symptoms using the OPCRIT checklist. Schizophrenia Research, 22:233-239, 1996.

Carpenter, W.T., Jr.; Heinrichs, D.W.; and Wagman, A.M. Deficit and nondeficit forms of schizophrenia: The con- cept. American Journal of Psychiatry, 145:578-583, 1988.

Cloninger, C.R.; Kaufmann, C.A.; Faraone, S.V.; Malaspina, D.; Svrakic, D.M.; Harkavy-Friedman, J.; Suarez, B.K.; Matise, T.C.; Shore, D.; Lee, H.; Hampe, C.L.; Wynne, D.; Drain, C; Markel, P.D.; Zambuto, C.T.; Schmitt, K.; and Tsuang, M.T. Genome-wide search for schizophrenia susceptibility loci: The NIMH Genetics Initiative and Millennium Consortium. American Journal of Medical Genetics, 81:275-281, 1998.

Andreasen, N.C. Methods for assessing positive and nega- tive symptoms. Modern Problems of Pharmacopsychiatry, 24:73-88, 1990.

Arndt, S.; Alliger, R.J.; and Andreasen, N.C. The distinc- tion of positive and negative symptoms: The failure of a two-dimensional model. British Journal of Psychiatry, 158:317-322, 1991.

Arndt, S.; Andreasen, N.C; Flaum, M.; Miller, D.; and Nopoulos, P. A longitudinal study of symptom dimensions in schizophrenia: Prediction and patterns of change. Archives of General Psychiatry, 52:352-360, 1995.

Brzustowicz, L.M.; Honer, W.G.; Chow, E.W.; Hogan, J.; Hodgkinson, K.; and Bassett, A.S. Use of a quantitative trait to map a locus associated with severity of positive symp- toms in familial schizophrenia to chromosome 6p. American Journal of Human Genetics, 61:1388-1396, 1997.

Faraone, S.V.; Blehar, M.; Pepple, J.; Moldin, S.O.; Norton, J.; Nurnberger, J.I.; Malaspina, D.; Kaufmann, C.A.; Reich, T.; Cloninger, C.R.; DePaulo, J.R.; Berg, K.; Gershon, E.S.; Kirch, D.G.; and Tsuang, M.T. Diagnostic accuracy and confusability analyses: An application to the Diagnostic Interview for Genetic Studies. Psychological

Medicine, Kay, S.

26:401-410,1996. Positive and Negative

Syndromes

in

Schizophrenia. New York, NY: Brunner/Mazel, 1991.

Kay, S.R.; Fiszbein, A.; and Opler, L. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin, 13(2):261-276, 1987.

Kendler, K.S.; Karkowski, L.M.; and Walsh, D. The struc- ture of psychosis: Latent class analysis of probands from the Roscommon Family Study. Archives of General Psychiatry, 55:492-499, 1998.

Cardno, A.G.; Holmans, P.A.; Harvey, I.; Williams, M.B.; Owen, M.J.; and McGuffin, P. Factor-derived subsyn- dromes of schizophrenia and familial morbid risks. Schizophrenia Research, 23:231-238, 1997.

Kirkpatrick, B.; Buchanan, R.W.; McKenney, P.D.; Alphs, L.D.; and Carpenter, W.T., Jr. The Schedule for the Deficit Syndrome: An instrument for research in schizophrenia. Psychiatry Research, 30:119-123, 1989.

693

Document info
Document views29
Page views29
Page last viewedFri Oct 28 08:43:52 UTC 2016
Pages13
Paragraphs837
Words7598

Comments