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Tykerb was selected for progression to clinical trials based on 22 selection criteria which included:

  • Efficacy parameters (cellular and in vivo)

  • Biometabolism parameters (time of drug exposure, %F, p450 enzymes)

  • Toxicity (cellular, cardiovascular, 7 day rat studies, Ames, etc)

  • Chemical issues (cost of goods and scaleability)

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