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Structure of Tykerb and Competitor Molecules

F

Cl

F

Cl

O

N

N

N

N

N H

N

N H

N

N H

Erlotinib

Gefitinib

Tarceva

Iressa

Small head group quinazolines

O

N

  • O

    O

  • O

    O

OO

O

HN

S

  • O

    O

GW572016/Lapatinib Tykerb

Large head group quinazoline

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