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(nM)

(nM)

(nM)

Tykerb

3.0 +/- 0.2

13 +/- 1

347 +/- 16

In Vitro Potency of Tykerb vs Competitor Molecules

Compound

EGFR Kiapp

ErbB2 Kiapp

ErbB4 Kiapp

Gefitinib

0.4 +/- 0.1

870 +/- 90

1130 +/- 370

Erlotinib

0.7 +/- 0.1

1000 +/- 100

1530 +/- 270

Wood et al., Proc AACR 2003, 44 #6187

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