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In Vivo Effects Correlate with In Vitro Half Life

Recovery of EGFR phosphorylation in HN5 cells treated with ErbB inhibitors for 4hr

  • 0

    hr

24 hr

48 hr

72 hr

96 hr

V

L

G

E

V

L

G

E

V

LG

E

V

L

GE

V

L

G

E

pEGFR

EGFR

Key:

V = Treated with DMSO L = Treated with Lapatinib G = Treated with Gefitinib E = Treated with Erlotinib

Wood et al Cancer Res 2004: 64, 6652

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