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Dual ErbB2 (13nM) and ErbB1 (3nM) inhibitor

Highly selective for ErbB2 and ErbB1 versus other kinases

Excellent cell potency <0.2 μM Efficacious in xenograft models

Inhibits ErbB1 and ErbB2 p-Tyr, p- ERK1/2, p-AKT, cyclin D in tumor cell lines and xenografts

Tykerb Properties

N-{3-Chloro-4-[(3- fluorobenzyl)oxy]phenyl}-6-[5-({[2- (methylsulfonyl)ethyl] amino}methyl)- 2-furyl]-4-quinazolinamine

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