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MEDICATION GUIDE

Boniva® (bon-EE-va) (ibandronate) Injection for intravenous use

Read the Medication Guide that comes with BONIVA before you start taking it and each time you get a refill. There may be new information. This Medication Guide does not take the place of talking with your doctor about your medical condition or treatment. Talk to your doctor if you have any questions about BONIVA.

What is the most important information I should know about BONIVA?

BONIVA Injection is given in your vein (intravenously) and only given by a healthcare provider. Do not give BONIVA Injection to yourself.

BONIVA may cause serious side effects including:

    • 1.

      Low calcium levels in your blood (hypocalcemia)

    • 2.

      Severe allergic reaction (anaphylactic reaction)

    • 3.

      Severe kidney problems

    • 4.

      Severe jaw bone problems (osteonecrosis)

    • 5.

      Bone, joint or muscle pain

    • 6.

      Unusual thigh bone fractures

  • 1.

    Low calcium levels in your blood (hypocalcemia). BONIVA may lower the calcium levels in your blood. If you have low blood calcium before you start taking BONIVA, it may get worse during treatment. Your low blood calcium must be treated before you receive BONIVA. Most people with low blood calcium levels do not have symptoms, but some people may have symptoms. Call your doctor right away if you have symptoms of low blood calcium such as:

  • Spasms, twitches, or cramps in your muscles

  • Numbness or tingling in your fingers, toes, or around your mouth

Your doctor may prescribe calcium and vitamin D to help prevent low calcium levels in your blood, while you receive BONIVA. Take calcium and vitamin D as your doctor tells you to.

2. Severe allergic reactions.

Some people who received BONIVA Injection had severe allergic reactions (anaphylactic reactions) that led to death. Get medical help right away if you have any of the symptoms of a serious allergic reaction such as:

  • Swelling of your face, lips, mouth or tongue

  • Trouble breathing

  • Wheezing

  • Severe itching

  • Skin rash, redness or swelling

  • Dizziness or fainting

  • Fast heartbeat or pounding in your chest

  • Sweating

Reference ID: 3295864

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