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diagnosed daily in the US. Eight hundred people have been diagnosed since we have

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gathered here today, since 8:00 this morning. Diabetes complications are increasing,

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which in turn is driving costs. 55 people with diabetes go blind daily, 120 more start

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dialysis, and 230 will require an amputation, just after today. The cost to the quality of

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life can’t be understated. The economic costs are increasing so quickly that they are

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creating an unimaginable burden on our healthcare system.

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needed. First, as mentioned today earlier by Dr. Wolf and others, we are not achieving

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our goals as patients with diabetes. Our success rate, if you will, is really low. You

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might say it’s abysmally low. Only about 55% of people with diabetes in the United

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States are at their glycemic targets and only 7% of patients with diabetes are at their

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glycemic, lipid and blood pressure targets, 93% of us are outside of that target zone in at

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least one area. Patients may be able to benefit from better, more tolerable, more

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convenient and simpler medications.

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accounted for 17% if healthcare spending. A significant chunk of this was tied to

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preventable complications. So we didn’t need to be spending that money on diabetes, we

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didn’t need to be spending it at all. According to the most recent data from the American

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Diabetes Association, between 2002 and 2007 the direct cost of diabetes increased from

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92 billion to 116 billion. Many of you have heard these numbers over and over; they are

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quite often quoted. You know, the real story is really what’s behind those numbers. In

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Second, prevalence is up. Four thousand people with diabetes are

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In 2006, people with diabetes represented 7% of the population but

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the rationale for the “one-size fits all” cardiovascular risk exclusion standard, again,

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in the absence of pre-clinical or clinical signals of actual or potential risk.

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So let me explain why I think new treatments for people with diabetes are

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