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DR. CHEN: Could I have slide 2-101 please. This slide summarizes the

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baseline creatinine clearance at baseline for our phase 2/phase 3 pool population. Data

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are shown for the various Saxagliptin doses, all Saxagliptin in control. We have broken

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this out into creatinine clearance of less than 50. We have cut the 50-80 range into two

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categories - that is 50-65 milliliters per minute, 65-80, and greater than 80. As Dr. Wolf

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have long-term duration experience in our clinical program. If I could have the slide that

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shows the experience, please project slide 3-51. This slide summarizes the experience in

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our phase 2b/phase 3 program for patients who had at least five years’ or ten years’

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duration of type 2 diabetes. Please note that approximately 20-30% and in some cases

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40% of patients had at least five years of disease. You see the experience for at least ten

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years. This slide also displays the experience for creatinine clearance below 80. I know

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that you asked for greater detail and that’s what we are going to provide to you now. Dr.

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Chen...

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50. This distribution was largely a consequence of our broad use of Metformin in our

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clinical program and the Metformin package label, which actually contra-indicates

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patients who have serum creatinines of greater than 1.5 or 1.4, depending on gender. As

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Dr. Wolf mentioned earlier we are conducting a renal study in patients with moderate,

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severe, or end-stage renal disease to gain more experience in this patient population.

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at the experience with skin cancers in the clinic and again we saw no evidence for a

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signal for increase in skin cancers among Saxagliptin-exposed patients.

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mentioned earlier, the majority of patients had a creatinine clearance that was greater than

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80 at baseline. About 16% of those patients had creatinine clearances between 50 and 80.

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There was a comment during the morning proceedings about whether we

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About 1 to 1.5%, a small minority, had creatinine clearances of less than

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