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patient population it sort of came to me today when I was looking at the characteristics of

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the patient population that was in this study average age, and correct me if I am wrong on

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any of this, the average age was about early 50s and with a relatively recent onset of type

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2 diabetes. As John Teerlink pointed out, the cardiovascular risks are much more

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pronounced in populations that are 65 and older and have had diabetes for ten years or

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more, certainly longer than the peak patients in this population had, in the study.

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view and take a sort of a 30,000-foot look at this. When I looked at question number one

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I really thought that it sort of got to the heart of the matter, no pun intended with that.

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Because, for me, it was one of relevance and when I was trying to dissect this and get

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away from torturing myself with very daunting statistics, I started looking at this low

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event rate and said, so what does that mean?

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assessment most relevant and it’s for those older patients, it’s for those ones who have

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these events who were not represented highly in this particular study. So, you know,

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going back to prior concerns that I voiced, I look at this idea of setting a cardiovascular

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risk hurdle for new drugs may place a burden on those diabetics who don’t fit into those

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parameters; the ones who develop type 2 diabetes, as we know it, at an increasingly

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younger age. When I was first diagnosed, they first thought I was a type 2 diabetic and

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they said, “Well that’s strange because it’s usually old, sedentary, obese people.” I was

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38 and I was training for a marathon and I just didn’t fit in that. It turned out eventually I

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was type 1 but they looked at me as a type 2 at first.

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Why is there a low event rate? When I looked at it and I looked at the

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So you are looking at, you know, for whom is this cardiovascular risk

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DR. BURMAN: Ms. Killion.

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DR. KILLION: Thank you. I wanted to step back from a patient point of

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