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of... So I think we agree that we have a certain body of evidence that’s applicable to this

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population. I guess the question at hand is, what level of concern might we have for a

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different population? That is, a population for example with established coronary

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disease. The truth of the matter is that we don’t have the exposure but I guess I am sort

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of throwing back, Do we have the reason to believe that the relative risk would go in one

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direction in this population and in another direction in that population?

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DR. TEERLINK: I think it’s not.

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DR. KONSTAM: Do you have evidence that it actually - do you have

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DR. SAVAGE: I agree with several of the comments Marvin has made

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and so forth, but I think that - and I feel reasonably reassured from the data that I have

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absolute risk. Okay. So the absolute risk in a non-ischemic heart disease population

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from these drugs is small but as far as I know, the relative risk is the same. That there is

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an increased relative risk, it’s not true. Well, how do you know it is not true? I think it is

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true.

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DR. BURMAN: This issue is a little off point.

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DR. KONSTAM: Well, but I think where it is on point is the question

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particular reason to be concerned about some of the others. Although, theoretically that’s

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possible. I think one of things that we have learned from the publication of several large

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enough evidence? I mean I am not sure how we know that.

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seen, certainly for the patients that were in the studies, but at least I don’t have a

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DR. TEERLINK: I tried to address that by suggesting that it’s hard to

have coronary events if you don’t in fact have underlying coronary disease.

DR. BURMAN: Thank you. Are there any other comments please? Dr.

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Savage.

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