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we didn't see quantitative changes in those markers. I did want to mention though that,

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and this is very speculative of course, but some of the substrates of DPP-4 have been

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hypothesized to have cardioprotective effects and those substrates would include GLP-1,

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stromal cell derived factor-1 and perhaps even RANTES. I think that that's very

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speculative, the bottom line is to really properly assess as we intend to do a properly

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sized randomized control to really address the question directly.

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you mentioned about the hypothesis generating aspects of the data whether you looked at

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the various pooled analyses of primary MACE or custom MACE, it seems to be on a

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favorable side, obviously the hypothesis generating for which you are going to be testing

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in your upcoming outcome trial, and I wanted to just ask you, can you give us any

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information perhaps on any data you may have on proinflammatory markers that

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potentially could explain beyond just the hemoglobin A1c, potential benefits?

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DR. KONSTAM: Yeah, I have got a few questions. One is, I know this is

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principally about safety, but I sort of think about safety signals relative to the incremental

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DR. WOLF: We have looked at proinflammatory markers in our program,

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DR. BURMAN: Thank you. Dr. Veltri?

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DR. VELTRI: Yeah, this is for Bob Wolf. Bob, I was also intrigued as

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DR. WOLF: You know, we haven't seen a treatment affect an HSCRP.

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DR. BURMAN: Thank you, Dr. Konstam?

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clinical benefit that a drug might offer relative to other things in the market and I think

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the thing that one of the things you have stressed is the low potential for hypoglycemia,

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and I understand the concept of it very well. I just wondered if you can help me out

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DR. VELTRI: I guess the question I have, have you looked at for

instance, HSCRP?

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