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think that studying macro-vascular events will make an important contribution in the area

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of type 2 diabetes. So we are at this time focused on making certain studies properly

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sized and designed to address that issue because that would make the most important

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contribution to the field.

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questions and one was just a follow on related to the event driven trial that you have

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mentioned, and my question was are the events driving this, are they going to be macro-

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vascular events; micro-vascular events or both? The reason I am asking is obviously we

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are all interested in a CV outcomes trial. Glucose control hasn't been shown to decrease

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macro-vascular events. It has been shown to decrease micro-vascular events and we are

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assuming that that is the same for this class of agents, which have not yet been shown to

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decrease micro-vascular events. So I am just curious what these events actually are going

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to be.

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DR. WOLF: Again, the design of that study is still under discussion. We

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understand a little bit better the cardiovascular risk level of these patients, and I just had a

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couple of specific questions. When you reported the percent that had

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hypercholesterolemia, was that based on their reported past medical history or their

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baseline lipid profile at entry?

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DR. WYNE: Yes. I had two questions related to Dr. Teerlink's

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DR. WYNE: Thank you, and my other question is just trying as he was to

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whether or not there was any specific Statin used at a high level in either of the specific

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studies or the global population?

DR. WOLF: That was based upon the reported past medical history by the

DR. WYNE: Okay. Do you know what percent were on Statins and

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patient.

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