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by System Organ Class or SOC for the short-term period. The majority of “Custom

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MACE” events in the short-term period fell into the cardiac disorders SOC, with 0.1% of

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subjects in the 10 milligram group versus 0.4% in the comparator group. Under nervous

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system disorders, events were balanced across all groups with an incidence of less than

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0.1% or 0.1% throughout.

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groups are pooled. Therefore the incidence of “Custom MACE” events in the all

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Saxagliptin group for the short-term period is 0.1% versus 0.6% in the comparator, and

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0.7% in all Saxagliptin groups versus 1.4% in the comparator for the short-term plus

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long-term period. Note that there are twice as many subjects in the Saxagliptin groups

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versus placebo, even when patient years were taken into account, the results were

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consistent.

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have listed all the preferred terms that occurred under that SOC which were four. Only

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one myocardial infarction occurred in a Saxagliptin treated subject, while each of these

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events occurred at least once in the comparator group. Here is the breakdown of

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preferred terms under the nervous system disorders SOC for the short-term period. CVA

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Again this is the same data I have been showing you but now broken down

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Again, the same data but now I zoom in on the cardiac disorders SOC

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Overall, there were a few events noticed, one event here, one event here, two events

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here. In the short-term period, only the Saxagliptin treatment groups had incidences of

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less than 0.1% to 0.2% versus 0.6% in the comparator. In the short-term plus long-term

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periods, overall events remained low with incidences of 0.5% to 1.1% in the Saxagliptin

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groups versus 1.4% in the comparator group.

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This is the same data I have just shown. However, all of the Saxagliptin

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