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first cover the SMQ results, and then the “Custom MACE” results. Now here I am

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showing you the results for SMQ using the three estimates I mentioned earlier. At the

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top is the risk difference, and here is the scale for the risk difference that goes from –1%

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to 1%. The scale for the ratios is a log scale and it goes from 0.02 to 5. Now it's very

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clear that there is no difference between the rate ratio and the odds ratio results, that's

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with these estimates, and that all the results present produce estimates that are close to

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this no difference line.

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intervals for the overall MACE results. Now I have drawn three lines on the graph, one

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at 1 and then one at 1.3 and 1.8. You can see we have the two estimates depicted on this

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graph. All the plots of the odds ratio that I will show contain a line at one and so

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estimates to the left of the line indicate results favorable to Saxagliptin, and estimates to

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the right are unfavorable. Now in addition to the short-term plus long-term results that

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you saw in the companies presentation, that is noted here as ST plus LT, we are depicting

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here the results from the 24 week short-term period. That is ST. The message though is

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the same regardless of which time period you use. The “Custom MACE” upper limit is

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well under 1.8 and close to one. The upper limit of the broader endpoint is also less than

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1.8 and a little above 1.3.

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have listed the studies in numerical order with the incidences to note here and then the

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odds ratios. I want to point out that there are no trials without events. The bulk of the

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events come from the course studies, so are these trials with the 12-week studies depicted

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at each end of the graph. Dr. Lowy described some of the events that were observed for

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Now we would like to show you some specifics about these results. I will

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Now here is the Forest plot of the SMQ results using the full exposure. I

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So here are the stratified common odds ratios and 95% confidence

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