DR. MELE: Right, we couldn’t keep going breaking it down because of
the fact that you do have so few events. I mean, once you got to over ten, you are going
that most of these cardiovascular events, the increased risk of cardiovascular events
doesn't really start occurring in patients with diabetes until they have had diabetes for ten
years. Do we have in the group who had diabetes for ten years or more any evidence of
what happens with those patients?
DR. MELE: Exactly, right.
DR. BURMAN: Thank you. Dr. Veltri.
DR. VELTRI: Yeah a comment and a question. I gather we find
patients who are above 65, that’s where it starts to shift over to the other direction. Is
there anything that we have and to - and granted with huge confidence intervals, but
that’s just because we have no events.
DR. MELE: We didn’t specifically look at duration, but we just broke it
down by the two types of studies which does sort of get you there, but doesn't look at the
ourselves here because obviously there wasn’t any prospect of adjudication of events and
really what we are trying to do here is to get a better sense of the reality I guess of what
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Do we have anything in terms of previous duration of diabetes? Given
to have, I don’t know what the number is, but it is going to be so few events, it is not
going to be worth analyzing.
DR. TEERLINK: The point being there are almost no patients in this trial
who have had diabetes for more than ten years in the entire development program.
DR. TEERLINK: I mean differences like from two years to five years,