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DR. MELE: Right, we couldn’t keep going breaking it down because of

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the fact that you do have so few events. I mean, once you got to over ten, you are going

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that most of these cardiovascular events, the increased risk of cardiovascular events

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doesn't really start occurring in patients with diabetes until they have had diabetes for ten

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years. Do we have in the group who had diabetes for ten years or more any evidence of

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what happens with those patients?

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DR. MELE: Exactly, right.

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DR. BURMAN: Thank you. Dr. Veltri.

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DR. VELTRI: Yeah a comment and a question. I gather we find

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patients who are above 65, that’s where it starts to shift over to the other direction. Is

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there anything that we have and to - and granted with huge confidence intervals, but

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that’s just because we have no events.

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DR. MELE: We didn’t specifically look at duration, but we just broke it

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down by the two types of studies which does sort of get you there, but doesn't look at the

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ourselves here because obviously there wasn’t any prospect of adjudication of events and

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really what we are trying to do here is to get a better sense of the reality I guess of what

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Do we have anything in terms of previous duration of diabetes? Given

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to have, I don’t know what the number is, but it is going to be so few events, it is not

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going to be worth analyzing.

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DR. TEERLINK: The point being there are almost no patients in this trial

who have had diabetes for more than ten years in the entire development program.

DR. TEERLINK: I mean differences like from two years to five years,

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upper end.

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right?

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