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JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY

HYDERABAD

IV Year B.Tech. IT II-SemT P C

4+1*04

BIOINFORMATICS

(ELECTIVE-IV)

UNIT-I

Introduction to Bioinformatics: Scope of Bioinformatics, Elementary commands and protocols, ftp, telnet, http. Primer on information theory.

UNIT-II

Introduction to Homology : Introduction to Homology (with special mention to Charles Darwin, Sir Richard Owen, Willie Henning, Alfred Russel Wallace).

UNIT-III

Special Topics In Bioinformatics : DNA mapping and sequencing, Map alignment, Large scale sequencing methods Shotgun and Sanger method.

UNIT-IV

Sequencing Alignment and Dynamic Programming : Heuristic Alignment algorithms. Global sequence alignments-Neddleman-Wunsch Algorithm Smith-Waterman Algorithm-Local sequence alignments (Amino acid substitution Matrices (PAM, BLOSUM).

UNIT-V

Primary Database and their Use : Introduction to Biological databases, Organization and management of databases. Searching and retrieval of information from the World Wide Web. Structure databases-PDB (Protein Data Bank), Molecular Modeling Databases (MMDB). Primary Databases NCBL,EMBL, DDBJ.

UNIT-VI

Secondary Databases : Introduction to Secondary Databases Organization and management of databases Swissprot, PIR,KEGG

UNIT-VII

Bio Chemical Data Bases : Introduction to BioChemical databases-organization and Management of databases. KEGG, EXGESCY, BRENDA, WIT.

UNIT-VIII

Evolutionary Trees and Phylogeny : Multiple sequence alignment and phylogenetic analysis.

TEXT BOOKS :

1. Bioinformatics Basics. Applications in Biological Science and Medicine by

   Hooman H. Rashidi and Lukas K.Buehler CAC Press 2000.

2. Algorithms on Strings Trees and Sequences Dan Gusfiled. Cambridge

    University Press 1997.

REFERENCES :

1. Bioinformatics: A Machine Learning Approach P. Baldi. S. Brunak, MIT Press    

   1988.

2. Bioinformatics. David Mount, 2000. CSH Publications

3. Developing Bioinformatics Skills. Cynthia Gibbas & Per Jamberk

4. Genomics and Proteomics-Functional and Computational aspects. Springer

   Publications. Editior-Sandor Suhai.

5. Bioinformatics- Methods and Protocols-Human Press. Stephen Misener,

   Stephen A. Krawetz.

6. Computational Biochemistry – C.Stan ,TSAI WILEY Publications.

7. Bioinformatics – A Practical guide to the Analysis of Genes and Proteins –

  ANDREAS D.BAXEVANIS, B.F. FRANCIS OUELLETTE.

8. Bioinformatics – Principles and Applications – Harshawardhan P.Bal TATA

   MEGRAW HILL.

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