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Quality by Design: Next Steps to Realize Opportunities? - page 25 / 37

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Metoprolol IR Tablets: In Vitro - In Vivo Relationship

TIME IN MINUTES

0

5

10

15

20

25

30

35

0

10

20

30

40

50

60

70

80

90

100

110

Rapid

Slow

FDA-UMAB

(931011)

RATIO (T/R) OF % DISSOLVED AT

10 MINUTES

0.2

0.4

0.6

0.8

1.0

1.2

0.5

0.6

0.7

0.8

0.9

1.0

1.1

1.2

FDA-UMAB

(931011)

AUC

Cmax

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