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Quality by Design: Next Steps to Realize Opportunities? - page 26 / 37

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Metoprolol IR Tablets: Experimental & Simulation Data

RATIO (T/R) OF % DISSOLVED AT 10 MINUTES

0.2

0.4

0.6

0.8

1.0

1.2

0.5

0.6

0.7

0.8

0.9

1.0

1.1

1.2

AUC

Cmax

Plot 1 Regr

0.1

0.2

0.3

0.4

0.5

0.0

0.5

1.0

1.5

2.0

0.0

0.5

1.0

1.5

2.0

0.75

0.80

0.85

0.90

0.95

0.70

0.75

0.80

0.85

0.90

0.95

Mean Intestinal Transit Time = 3.33 h

Mean Intestinal Transit Time = 1.67 h

85%

D

I

S

S

O

L

U

T

I

O

N

T

I

M

E

(h)

Gastric Emptying Half-Time (h)

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