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Table II: ICRP and Manufacturers' Data on Effective Doses, Total Body Doses, and Absorbed Doses per Unit Activity of 99mTc Sestamibi and Tetrofosmin

Radiopharmaceutical

99mTc Sestamibi

99mTc Tetrofosmin

Data Source

ICRP 80

PI

ICRP 80

PI

Rest/stress (void time)

Rest

Stress

Rest (2h)

Rest (4.8h)

Stress (2h)

Stress (4.8h)

Rest

Stress

Rest

Stress

Effective Dose (E/A in mSv/MBq)

9.0E-03

7.9E-03

-

-

-

-

7.6E-03

7.0E-03

1.1E-02

8.6E-03

Total Body Dose (in mGy/MBq)

-

-

4.3E-03

4.3E-03

3.8E-03

3.8E-03

-

-

-

-

Organ Absorbed Doses (DT/A in mGy/MBq)

    Adrenals

7.5E-03

6.6E-03

3.4E-03

3.3E-03

4.1E-03

4.3E-03

    Bladder

1.1E-02

9.8E-03

1.8E-02

3.7E-02

1.4E-02

2.7E-02

1.7E-02

2.6E-02

1.9E-02

1.6E-02

    Bone

8.2E-03

7.8E-03

6.1E-03

5.8E-03

5.6E-03

5.4E-03

4.5E-03

4.8E-03

5.6E-03

6.2E-03

    Bone Marrow

5.5E-03

5.0E-03

4.6E-03

4.5E-03

4.1E-03

4.0E-03

2.9E-03

2.9E-03

4.0E-03

4.1E-03

    Brain

5.2E-03

4.4E-03

3.9E-04

4.6E-04

2.2E-03

2.7E-03

    Breasts

3.8E-03

3.4E-03

1.8E-03

1.7E-03

1.8E-03

1.6E-03

9.0E-04

1.0E-03

1.8E-03

2.2E-03

    Colon

2.4E-02

1.9E-02

2.4E-02

1.8E-02

    Colon (lower large intestine)

1.9E-02

1.6E-02

3.6E-02

3.7E-02

2.9E-02

2.9E-02

2.0E-02

1.5E-02

2.2E-02

1.5E-02

    Colon (upper large intestine)

2.7E-02

2.2E-02

5.0E-02

5.0E-02

4.0E-02

4.0E-02

2.7E-02

2.0E-02

3.0E-02

2.0E-02

    Esophagus

4.1E-03

4.0E-03

2.1E-03

2.4E-03

    Gallbladder

3.9E-02

3.3E-02

1.8E-02

1.8E-02

2.6E-02

2.5E-02

3.6E-02

2.7E-02

4.9E-02

3.3E-02

    Heart

6.3E-03

7.2E-03

4.6E-03

4.4E-03

5.0E-03

4.8E-03

4.4E-03

4.8E-03

3.9E-03

4.1E-03

    Kidneys

3.6E-02

2.6E-02

1.8E-02

1.8E-02

1.5E-02

1.5E-02

1.4E-02

1.1E-02

1.3E-02

1.0E-02

    Liver

1.1E-02

9.2E-03

5.2E-03

5.1E-03

3.8E-03

3.7E-03

4.0E-03

3.3E-03

4.2E-03

3.2E-03

    Lungs

4.6E-03

4.4E-03

2.5E-03

2.4E-03

2.3E-03

2.2E-03

2.0E-03

2.2E-03

2.1E-03

2.3E-03

    Muscles

2.9E-03

3.2E-03

3.7E-03

4.1E-03

3.3E-03

3.5E-03

    Ovaries

9.1E-03

8.1E-03

1.4E-02

1.4E-02

1.1E-02

1.2E-02

8.4E-03

7.6E-03

9.6E-03

7.9E-03

    Pancreas

7.7E-03

6.9E-03

4.1E-03

3.9E-03

5.0E-03

5.0E-03

    Remaining Organs

3.1E-03

3.3E-03

3.9E-03

4.1E-03

    Salivary Glands

1.4E-02

9.2E-03

1.4E-02

9.3E-03

1.2E-02

8.0E-03

    Skin

3.1E-03

2.9E-03

1.3E-03

1.4E-03

1.9E-03

2.2E-03

    Small Intestine

1.5E-02

1.2E-02

2.7E-02

2.7E-02

2.2E-02

2.2E-02

1.5E-02

1.1E-02

1.7E-02

1.2E-02

    Spleen

6.5E-03

5.8E-03

3.0E-03

3.0E-03

3.8E-03

4.1E-03

    Stomach

6.5E-03

5.9E-03

5.5E-03

5.2E-03

4.8E-03

4.7E-03

3.7E-03

3.5E-03

4.6E-03

4.6E-03

    Testes

3.8E-03

3.7E-03

3.1E-03

3.5E-03

2.8E-03

3.1E-03

2.4E-03

2.9E-03

3.1E-03

3.4E-03

    Thalamus

    Thymus

4.1E-03

4.0E-03

2.1E-03

2.4E-03

2.5E-03

3.1E-03

    Thyroid

5.3E-03

4.4E-03

6.3E-03

6.3E-03

2.4E-03

2.2E-03

5.7E-03

4.8E-03

5.8E-03

4.3E-03

    Uterus

7.8E-03

7.2E-03

7.2E-03

7.6E-03

8.4E-03

7.3E-03

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