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Protection

Consistent 60-80% protection against disseminated tuberculosis (TBM, miliary TB) in HIV-negative and unexposed young children

Variable protection: pulmonary TB, limited impact transmission

Revaccination: no benefit

Cost-effective

Limited efficacy data in HIV-infected infants

High TB incidence HIV-infected infants (small subpopulation): 25 fold higher in HIV-infected infants

HAART: reduces risk of TB in HIV-infected infants

Trunz, Fine, Dye. The Lancet 2006; 367:1173-1180,

Rodrigues, Int J Epi 2002

EFFICACY: BCG  IS EFFECTIVE IN PREVENTING SEVERE TB IN CHIDREN

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