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BCG AND SAFETY

1. DISSEMINATED BCG DISEASE

Pre-HIV era: incidence 1 -5 per million vaccinees (Fine, 1997)

BCG poses a risk of disseminated BCG disease in infants vertically infected with HIV  Talbot et al, Clin Infect Dis 1997, Hesseling, 2003, Hesseling, 2006, Hesseling 2007)

WHO: BCG contra-indicated in individuals with symptomatic HIV infection (2004)

Risk quantification?

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