DR. DAVIS: What were your parameters on heart rate that made you feel comfortable with this dose?
DR. MARRONGELLE: He was a down-regulated parasympathetically violet, let's say, for the people who've seen a little bit on heart rate. And he was slightly in the lower left quadrant, sympathetically he was minus one. When I gave him the first dose, he moved to only on-level with sympathetic and minus two parasympathetic. So he moved about halfway toward center. When I gave him the second dose he was on-average level sympathetically and down-regulated one parasympathetically. Then when he stood up he only up-regulated one parasympathetic unit, which means he had a perfect normal nervous system response to standing up. He was only one unit to the left of dead center autonomically. It was an incredible move. And his rates and rhythms stayed very similar from one to the other. That's what we see with heart rate. Say a person's heart rate is 60 laying down and 70 standing up, it can be 61 on a repeat and 68, which is clinically insignificant--a beat or two different from both positions. But all the factors of autonomic control and the total power and the high frequency and low frequency waves from the brain to the myocardium will change. And the autonomic regulation will change without the rate and the rhythm of the heart changing, which means you've totally affected the autonomic nervous system. You haven't moved the heart rate a whole lot. What you've moved is the energy system and the brain's control of the heart rate. OK? You guys got that one?
DR. DAVIS: What was his AMV score?
DR. MARRONGELLE: His cardio-trophic myocardial response? It was like in the low 70's and then dropped to like 68. But the more important one was the vascular compensation, because that indicates how rapidly the brain readjusts your blood vessels to the standing position, and that's an important parameter in chronic fatigue. I'm going to transition into chronic fatigue off of this. OK? And explain some things we're seeing in chronic fatigue, so we're trying to transition to that.
This vascular compensation mechanism is when you stand up, your blood vessels should constrict to maintain appropriate blood pressure throughout the whole body. If there's a great disparity between the myocardial response and the vascular compensation response, then we know that something neurologically is disturbing the baro or chemo receptors and the brain is being blocked from the normal transmission of that information, either into the brain to have a reaction, or from the brain out to the blood vessels to cause the constriction. The more common thing you're going to see and maybe going unobserved in almost all of our practices--because I've seen it and I've picked it up occasionally over the years, but now that I'm looking for it, I see it more and more and more--is that in clients that have chronic fatigue and have chronic gastrointestinal problems have a Vagul nerve disturbance that leads to postural hypertension--or hypotension--and postural tachycardia--orthostatic tachycardia. When the person stands up, if the heart rate goes up extremely, and there's a strong parasympathetic response and a down-regulation of the parasympathetic system, you will have a corresponding drop in blood pressure. And if you take a standing blood pressure in most of these people with chronic fatigue,