X hits on this document

118 views

0 shares

5 / 9

# The Bonferonni and Šidák Corrections

α[PT ] =

number of significant tests total number of tests

=

2, 403 = .0479 . 50, 000

(1)

This value falls close to the theoretical value of α = .05.

For 7,868 families, no test reaches significance. Equivalently for 2,132 families (10,0007,868) at least one Type I error is made. From these data, α[PF ] can be estimated as:

number of families with at least 1 Type I error α[PF ] = total number of families

=

2, 132 = .2132 . 10, 000

(2)

# This value falls close to the theoretical value of

α[PF ] = 1 (1 α[PT ])C = 1 (1 .05)5 = .226 .

2.3

How to correct for multiple tests: Šidàk, Bonfer- onni, Boole, Dunn

Recall that the probability of making as least one Type I error for a family of C tests is

α[PF ] = 1 (1 α[PT ])C

.

This equation can be rewritten as

α[PT ] = 1 (1 α[PF ])1/C .

This formula—derived assuming independence of the tests—is some- times called the Šidàk equation. It shows that in order to reach a given α[PF ] level, we need to adapt the α[PT ] values used for each test.

Because the Šidàk equation involves a fractional power, it is dif- ficult to compute by hand and therefore several authors derived

5

 Document views 118 Page views 124 Page last viewed Fri Jan 20 06:01:49 UTC 2017 Pages 9 Paragraphs 123 Words 1977