sample. In addition, they pointed out that favorable trends for the risk factors for obesity, diabetes and hypertension may well continue to increase at levels greater than 92 nmol/L conferring additional health benefits. In addition, their results were regarded as consistent with the established literature that suggests a role for vitamin D in promoting insulin sensitivity and preventing diabetes. They also present plausible biological mechanisms for some
Editor’s comments: It is clear that there is a relationship between vitamin D status and a wide
variety of disorders.
This must be in part due to the
role vitamin D plays cellular processes. In
in a very large number addition, as indicated in
reviewed above, humans tolerate of vitamin D without any apparent
very large ill effects.
Also, a recent paper that of an intervention study
results D and
of the observed dependencies on vitamin D. Martins, D. et al. Prevalence of Cardiovascular Risk Factors and the Serum Levels of 25-Hydrfoxyvitamin D in the United States. Archives on Internal Medicine, 2007, Vol. 167, June 11, pp. 1159-1165.
cardiovascular 54) will not be
events (Circulation, 2007;115:846- reviewed simply because the doses
used for vitamin is not surprising
D were so small (400 no effect was seen.
BEHAVIOR IN CHILDREN A randomized, double-blind,
study has just reported that tested artificial food color and other additives in the context of hyperactivity in 153 3-year olds and 144 8- to 9-year olds. Both parents and teachers were involved in rating the outcomes. Aside from the artificial food- coloring agents, sodium benzoate was the only other additive tested. Significant adverse effects were observed for artificial coloring agents or sodium benzoate preservative or both in that these substances increased hyperactivity in both age groups, a result that the authors suggest extends to the general population of children in these age
groups. McCann, D. et al.
Food Additives and Hyperactive
Behavior in 3-Year-old and 8/9-year-old Children in the
Community. A Controlled Trial.
Randomized, Double-Blinded, placebo- Lancet, 2007, published ahead of print
(twice the relative risk). In addition, for those with MRI data available, the risk of atherosclerotic plaque in the aorta was three times higher in those with the largest WHR compared to the smallest WHR. WHR was also found to be a better predictor of coronary calcification than the body mass index or waist circumference alone. WHR for the lowest and highest quintiles were < 0.906 and > 1.009 for
men and < 0.802 and > Abdullah, S.M. et al. Measures of Overweight
0.92 The and
Atherosclerosis. Journal of the American Cardiology, 2007, Vol. 50, pp. 752-59.
MAGNESIUM INTAKE AND THE RISK OF
TYPE-2 DIABETES There have been a number of observational studies
of the association diabetes, but the totally consistent.
of magnesium intake and type-2 picture that emerged was not In a recent meta-analysis of 7
cohort studies of magnesium from supplements, the combined participant
foods or population
WAIST-TO-HIP RATIO ATHEROSCLEROSIS
Investigators obtained data from the Dallas Heart Study which involved a large, multiethnic urban population of patients on whom electron beam tomography had been done to access coronary plaque and where MRI data was available to determine aortic plaque. It was found that the likelihood of coronary calcification, i.e. coronary atherosclerosis, increased in direct proportion to increases in waist-to-hip ratio (WHR). Individuals in the highest as compared to the lowest quintiles of WHR had greater than a four times increased in risk
of prevalent coronary calcification. remained after correcting for standard
was 286,669 with overall relative risk magnesium intake with similar results
10,912 cases of diabetes. The per 100 mg per day increase in was 0.85 (15% risk reduction) when the data was stratified for
even though 4
individually failed to The authors point
achieve statistical significance. out that one hundred mg of
magnesium whole grain beans, 1.4
would be supplied by four slices of bread, four cups of oatmeal, one cup of cup of nuts, 4 tablespoons of peanut
butter, ½ per day, reduction
cup of cooked spinach or and would on average of the risk of diabetes.
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